RIKEN Center for Life Science Technologies

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To let you know about our research, this area contains 4 types of information about CLST; “Article”, “Videos”, “Event” and “Study”.
At “Article”, you can read articles on interviews and lectures, and you can enjoy the videos about CLST at “Videos”. If you want to meet and talk directly with the researcher, “Visit” give you some information of such events. You can find more difficult contents to know about our research deeply at “Study”.
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Labs & Technologies

Cellular Function Imaging Team

Investigating the functional roles of cells in living systems

Team Leader
Yosky Kataoka  M.D., Ph.D

6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan

3_4_kataoka.png

Research Area

We are investigating physiological or pathological roles of cells functioning in living tissues by using in vivo imaging methods including PET, MRI, fluorescence/bioluminescence imaging, microendoscope imaging, electron microscope imaging. In particular, we aim to establish new strategies for treating neurological disorders or malignancy by imaging stem/progenitor cells in the central nervous system or cancer/cancer stem cells. Further, we study metabolic dynamics in pathophysiological states including fatigue, and develop new techniques for controlling the living systems.

1) Molecular Imaging Research from Cellular level to whole body Level

We are developing new molecular imaging methodologies for stem/progenitor cells in the central nervous system and other organs. We are investigating novel physiological and pathological roles of stem/progenitor cells in cellular, tissue, organ, and whole body levels, using multi-modal imaging technologies including PET imaging, optical (fluorescence and bioluminescence) whole body imaging, and optical fiber microscopic imaging.

 

2) Research for Controlling Cellular/tissue Function in Living Systems

Recent studies indicate that chronic inflammation is deeply involved in neurological disorders, fatigue, and cancer. We aim to control such pathophysiological conditions by linking omics analyses including metabolome analysis, system biology (bioinformatics), and imaging technologies. In addition, we are developing new medical technologies using light energy or plasma for manipulation of immune reaction, tissue repair, and regeneration. 

[Media] 

PET imaging of adult neurogenesis may contribute to better diagnosis of depression and evaluation of drug therapy effectiveness

Main Publications List

1

Music Improves Subjective Feelings Leading to Cardiac Autonomic Nervous Modulation: A Pilot Study.

Kume S, Nishimura Y, Mizuno K, Sakimoto N, Hori H, Tamura Y, Yamato M, Mitsuhashi R, Akiba K, Koizumi JI, Watanabe Y, Kataoka Y.
Front Neurosci., 11(108), (2017).
2

NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival.

Nakano M, Tamura Y, Yamato M, Kume S, Eguchi A, Takata K, Watanabe Y, Kataoka Y.
Sci Rep., 7, 42041 (2017).
3

PET imaging of neurogenic activity in the adult brain: Toward in vivo imaging of human neurogenesis.

Tamura Y, Kataoka Y.
Neurogenesis (Austin), 4(1), e1281861 (2017).
4

Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles.

Yamano E, Sugimoto M, Hirayama A, Kume S, Yamato M, Jin G, Tajima S, Goda N, Iwai K, Fukuda S, Yamaguti K, Kuratsune H, Soga T, Watanabe Y, Kataoka Y.
Sci Rep., 6, 34990 (2016).
5

Noninvasive Evaluation of Cellular Proliferative Activity in Brain Neurogenic Regions in Rats under Depression and Treatment by Enhanced [18F]FLT-PET Imaging.

Tamura Y, Takahashi K, Takata K, Eguchi A, Yamato M, Kume S, Nakano M, Watanabe Y, Kataoka Y.
J Neurosci., 36(31), 8123-8131 (2016).
6

Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo.

Iwawaki T, Akai R, Oikawa D,, Toyoshima T, Yoshino M, Suzuki M, Takeda N, Ishikawa TO, Kataoka Y, Yamamura K.
Sci Rep., 5, 17205 (2015).
7

Potential biomarkers of fatigue identified by plasma metabolome analysis in rats.

Kume, S., Yamato, M., Tamura, Y., Jin, G., Nakano, M., Miyashige, Y., Eguchi, A., Ogata, Y., Goda, N., Iwai, K., Yamano, E., Watanabe, Y., Soga, T., Kataoka, Y.
PLoS One, 10(3), e0120106 (2015).
9

A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression.

Cui YL, Toyoda H, Sako T, Onoe K, Hayashinaka E, Wada Y, Yokoyama C, Onoe H, Kataoka Y, Watanabe Y.
Neuroimage, 108, 17-22 (2015).
10

Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: an 11C-(R)-PK11195 PET study.

Nakatomi Y, Mizuno K, Ishii A, Wada Y, Tanaka M, Tazawa S, Onoe K, Fukuda S, Kawabe J, Takahashi K, Kataoka Y, Shiomi S, Yamaguti K, Inaba M, Kuratsune H, Watanabe Y.
J Nucl Med, 55(6), 945-950 (2014).

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