RIKEN Center for Life Science Technologies


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To let you know about our research, this area contains 4 types of information about CLST; “Article”, “Videos”, “Event” and “Study”.
At “Article”, you can read articles on interviews and lectures, and you can enjoy the videos about CLST at “Videos”. If you want to meet and talk directly with the researcher, “Visit” give you some information of such events. You can find more difficult contents to know about our research deeply at “Study”.
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Labs & Technologies

Cellular Function Imaging Team

Investigating the functional roles of cells in living systems

Team Leader
Yosky Kataoka  M.D., Ph.D

6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan


Research Area

We are investigating physiological and pathological roles of cells functioning in living tissues by using in vivo imaging methods such as optical imaging, PET, and MRI. Also, we are developing new methods and techniques for controlling behavior and function of cells in living systems.

1) Molecular Imaging Research from Cellular level to whole body Level

We are developing new molecular imaging methodologies for stem/progenitor cells in the central nervous system and other organs. We are investigating novel physiological and pathological roles of stem/progenitor cells in cellular, tissue, organ, and whole body levels, using multi-modal imaging technologies including PET imaging, optical (fluorescence and bioluminescence) whole body imaging, and optical fiber microscopic imaging.


2) Research for Controlling Cellular/tissue Function in Living Systems

Recent studies indicate that chronic inflammation is deeply involved in neurological disorders, fatigue, and cancer. We aim to control such pathophysiological conditions by linking omics analyses including metabolome analysis, system biology (bioinformatics), and imaging technologies. In addition, we are developing new medical technologies using light energy or plasma for manipulation of immune reaction, tissue repair, and regeneration. 

Main Publications List


Potential biomarkers of fatigue identified by plasma metabolome analysis in rats.

Kume, S., Yamato, M., Tamura, Y., Jin, G., Nakano, M., Miyashige, Y., Eguchi, A., Ogata, Y., Goda, N., Iwai, K., Yamano, E., Watanabe, Y., Soga, T., Kataoka, Y.
PLoS One, 10(3), e0120106 (2015).

A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression.

Cui YL, Toyoda H, Sako T, Onoe K, Hayashinaka E, Wada Y, Yokoyama C, Onoe H, Kataoka Y, Watanabe Y.
Neuroimage, 108, 17-22 (2015).

Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: an 11C-(R)-PK11195 PET study.

Nakatomi Y, Mizuno K, Ishii A, Wada Y, Tanaka M, Tazawa S, Onoe K, Fukuda S, Kawabe J, Takahashi K, Kataoka Y, Shiomi S, Yamaguti K, Inaba M, Kuratsune H, Watanabe Y.
J Nucl Med, 55(6), 945-950 (2014).

Brain Interleukin-1 beta and the Intrinsic Receptor Antagonist Control Peripheral Toll-Like Receptor 3-Mediated Suppression of Spontaneous Activity in Rats

Yamato M, Tamura Y, Eguchi A, Kume S, Miyashige Y, Nakano M, Watanabe Y, Kataoka Y.
PLoS One, 9(3), e90950 (2014).

Functional neuroimaging of aversive taste-related areas in the alert rat revealed by positron emission tomography

Kobayashi M, Cui YL, Sako T, Sasabe T, Mizoguchi N, Yamamoto K, Wada Y, Kataoka Y, Koshikawa N.
J Neurosci Res, 91(10), 1363-1370 (2013).

Low-level laser therapy improves crescentic glomerulonephritis in rats

Yamato M, Kaneda A, Kataoka Y.
Lasers Med Sci, 28(4), 1189-1196 (2013).

Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly.

Toba S, Tamura Y, Kumamoto K, Yamada M, Takao K, Hattori S, Miyakawa T, Kataoka Y, Azuma M, Hayasaka K, Amamoto M, Tominaga K, Wynshaw-Boris A, Wanibuchi H, Oka Y, Sato M, Kato M, Hirotsune S.
Sci Rep, 3, 1224 (2013).

Neuroinflammation in animal models of fatigue.

Kataoka Y, Yamato M, Miyashige Y, Tamura Y, Cui Y.
Adv Neuroimmune Biol, 4, 237-244 (2013).

Cortical spreading depression shifts cell fate determination of progenitor cells in the adult cortex.

Tamura Y, Eguchi A, Jin G, Sami MM, Kataoka Y.
J Cereb Blood Flow Metab, 32(10), 1879-1887 (2012).

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