RIKEN Center for Life Science Technologies

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To let you know about our research, this area contains 4 types of information about CLST; “Article”, “Videos”, “Event” and “Study”.
At “Article”, you can read articles on interviews and lectures, and you can enjoy the videos about CLST at “Videos”. If you want to meet and talk directly with the researcher, “Visit” give you some information of such events. You can find more difficult contents to know about our research deeply at “Study”.
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Labs & Technologies

Protein Functional and Structural Biology Team

Establishment of a structural analysis technology platform that contributes to "life innovation" such as drug development and medical treatment.

Team Leader
Mikako Shirouzu  Ph.D.

#W209 West Research Building, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa, 230-0045, Japan
Tel: +81-(0)45-503-9202

1_1_shirouzu.png

Research Area

We plan to establish a structural analysis technology platform to contribute to "life innovation" such as drug discovery and medical treatment as well as develop methods for the sample preparation and crystallization of challenging proteins including membrane proteins that have been difficult in its analysis. The high-resolution structural information of proteins related to diseases shall increasingly become important for drug development leading to future individualized medicine such as a molecular target drug. Especially, we will perform structural analysis mainly for proteins related to immune system diseases and kinases associated with cancer/leukemia. The 3D-structural information of these target proteins will be used for in silico screening of chemical compounds. Further analysis of the complex of the target protein with candidate compounds will provide valuable information for drug discovery.

Main Publications List

1

Characterization of lysine acetylation of a phosphoenolpyruvate carboxylase involved in glutamate overproduction in Corynebacterium glutamicum.

Nagano-Shoji M, Hamamoto Y, Mizuno Y, Yamada A, Kikuchi M, Shirouzu M, Umehara T, Yoshida M, Nishiyama M, Kosono S.
Mol Microbiol., 104(4), 677-689 (2017).
2

Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A

Wang D, Nitta R, Morikawa M, Yajima H, Inoue S, Shigematsu H, Kikkawa M, Hirokawa N.
Elife, 5, e18101 (2016).
3

Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin.

Shinoda T, Shinya N, Ito K, Ohsawa N, Terada T, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Yokoyama S*, Shirouzu M*.
Sci Rep, 6, 33632 (2016).

Member  *concurrent

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