RIKEN Center for Life Science Technologies


  • Research

    Latest publications from CLST.
  • News

    Awards, agreements, and other news.
  • Events

    Upcoming and past events including seminars, symposiums, open days.

For Public

To let you know about our research, this area contains 4 types of information about CLST; “Article”, “Videos”, “Event” and “Study”.
At “Article”, you can read articles on interviews and lectures, and you can enjoy the videos about CLST at “Videos”. If you want to meet and talk directly with the researcher, “Visit” give you some information of such events. You can find more difficult contents to know about our research deeply at “Study”.
  • Article
  • Event
  • Videos
  • Study

Labs & Technologies

Pathophysiological and Health Science Team

―Utilizing Molecules― Translational study from animal to human

Team Leader
Yasuyoshi Watanabe  M.D., Ph.D.

6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan
Tel: +81-78-304-7101


Research Area

We provide core technologies to realize health sciences including very early diagnosis, patho-physiology, and preemptive medicine using imaging biomarkers closely related to disease state and pre-disease state (ahead sick), to innovate medical science with promotion of collaborations among all center members.

Main Publications List


Development of diagnostic techniques for early rheumatoid arthritis using positron emission tomography with 11C-PK11195 and 11C-ketoprofen tracers

Nozaki S, Ozaki N, Suzuki S, Goto M, Mawatari A, Nakatani Y, Hayashinaka E, Wada Y, Doi H, Watanabe Y.
Mol Imaging Biol.,, (2017).

Low putamen activity associated with poor reward sensitivity in childhood chronic fatigue syndrome

Mizuno K, Kawatani J, Tajima K, Sasaki AT, Yoneda T, Komi M, Hirai T, Tomoda A, Joudoi T, Watanabe Y.
Neuroimage Clin., 12, 600-606 (2016).

Less efficient and costly processes of frontal cortex in childhood chronic fatigue syndrome

Mizuno K, Tanaka M, Tanabe HC, Joudoi T, Kawatani J, Shigihara Y, Tomoda A, Miike T, Imai-Matsumura K, Sadato N, Watanabe Y.
Neuroimage Clin., 9, 355-368 (2015).

Synthesis of 11C-Labeled Thiamine and Fursultiamine for in Vivo Molecular Imaging of Vitamin B1 and Its Prodrug Using Positron Emission Tomography.

Doi H, Mawatari A, Kanazawa M, Nozaki S, Nomura Y, Kitayoshi T, Akimoto K, Suzuki M, Ninomiya S, Watanabe Y.
J Org Chem, 80(12), 6250-6258 (2015).

The neural mechanisms of re-experiencing mental fatigue sensation: a magnetoencephalography study.

Ishii A, Karasuyama T, Kikuchi T, Tanaka M, Yamano E, Watanabe Y.
PloS One, 10(3), e0122455 (2015).

A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression.

Cui YL, Toyoda H, Sako T, Onoe K, Hayashinaka E, Wada Y, Yokoyama C, Onoe H, Kataoka Y, Watanabe Y.
Neuroimage, 108, 17-22 (2015).

Quantitative evaluation of mMate1 function based on minimally invasive measurement of tissue concentration using PET with [11C]Metformin in mouse.

Shingaki T, Hume WE, Takashima T, Katayama Y, Okauchi T, Hayashinaka E, Wada Y, Cui Y, Kusuhara H, Sugiyama Y, Watanabe Y.
Pharm Res, in press, (2015).

[11C]Cetrozole: an Improved C-[11C]Methylated PET Probe for Aromatase Imaging in the Brain.

Takahashi K, Hosoya T, Onoe K, Doi H, Nagata H, Hiramatsu T, Li XL, Watanabe Y, Wada Y, Takashima T, Suzuki M, Onoe H, Watanabe Y.
J Nucl Med, 55(5), 852-857 (2014).

Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: an 11C-(R)-PK11195 PET study.

Nakatomi Y, Mizuno K, Ishii A, Wada Y, Tanaka M, Tazawa S, Onoe K, Fukuda S, Kawabe J, Takahashi K, Kataoka Y, Shiomi S, Yamaguti K, Inaba M, Kuratsune H, Watanabe Y.
J Nucl Med, 55(6), 945-950 (2014).

>>>ALL Publications

Member  *concurrent

  • >>>Curriculum vitae