RIKEN Center for Life Science Technologies

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To let you know about our research, this area contains 4 types of information about CLST; “Article”, “Videos”, “Event” and “Study”.
At “Article”, you can read articles on interviews and lectures, and you can enjoy the videos about CLST at “Videos”. If you want to meet and talk directly with the researcher, “Visit” give you some information of such events. You can find more difficult contents to know about our research deeply at “Study”.
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Labs & Technologies

Molecular Dynamics Imaging Unit

Unit Leader
Yi-Long Cui  Ph.D.

6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan
Tel: 078-304-7192

3_9_cui.png

Research Area

We aim to establish a PET imaging- based quantitative evaluation platform for pharmacokinetics in order to elucidate the molecular dynamics associated with the ADME (Absorption, Distribution, Metabolism, and Excretion) processes in living body, and aim to develop novel disease-specific PET imaging methods to evaluate drug efficacy, during the drug developmental process.

For the purpose of developing core technologies for comprehensively investigating the molecular dynamics in complex systems, we are also trying to establish an integrated research system combining PET imaging and classic research techniques, including electrophysiology, behavioral pharmacology, histology and genetic engineering approaches, and to thereby carry out comprehensive investigations covering the entire hierarchy of molecules, cells, organs and systems. We are especially interested in unlocking the mysteries of the brain, such as placebo analgesia and fatigue sensation.

Main Publications List

1

Extension of recovery time from fatigue by repeated rest with short-term sleep during continuous fatigue load: Development of chronic fatigue model

Kanzaki A, Okauchi T, Hu D, Shingaki T, Katayama Y, Koyama H, Watanabe Y, Cui Y.
J Neurosci Res, 94(5), 424-429 (2016).
2

A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression.

Cui YL, Toyoda H, Sako T, Onoe K, Hayashinaka E, Wada Y, Yokoyama C, Onoe H, Kataoka Y, Watanabe Y.
Neuroimage, 108, 17-22 (2015).
3
4

Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with F-18-incorporated oligodeoxynucleotides

Mukai H, Ozaki D, Cui Y, Kuboyama T, Yamato-Nagata H, Onoe K, Takahashi M, Wada Y, Imanishi T, Kodama T, Obika S, Suzuki M, Doi H, Watanabe Y.
J Control Release, 180, 92-99 (2014).
5

Positron emission tomography study on pancreatic somatostatin receptors in normal and diabetic rats with Ga-68-DOTA-octreotide: A potential PET tracer for beta cell mass measurement

Sako T, Hasegawa K, Nishimura M, Kanayama Y, Wada Y, Hayashinaka E, Cui YL, Kataoka Y, Senda M, Watanabe Y.
Biochem Biophys Res Commun, 442(1-2), 79-84 (2013).
6

Evaluation of Oatp and Mrp2 Activities in Hepatobiliary Excretion Using Newly Developed Positron Emission Tomography Tracer [C-11]Dehydropravastatin in Rats

Shingaki T, Takashima T, Ijuin R, Zhang X, Onoue T, Katayama Y, Okauchi T, Hayashinaka E, Cui YL, Wada Y, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
J Pharmacol Exp Ther, 347(1), 193-202 (2013).
7

Positron emission tomography studies using (15R)-16-m-[11C]tolyl-17,18,19,20-tetranorisocarbacyclin methyl ester for the evaluation of hepatobiliary transport.

Takashima T, Nagata H, Nakae T, Cui YL, Wada Y, Kitamura S, Doi H, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
J Pharmacol Exp Ther, 335(2), 314-323 (2010).
8

Mapping of regional brain activation in response to fatigue-load and recovery in rats with c-Fos immunohistochemistry.

Akazawa KH, Cui YL, Tanaka M, Kataoka Y, Yoneda Y, Watanabe Y.
Neurosci Res, 66(4), 372-379 (2010).
9

11C-PK11195 PET for the in vivo evaluation of neuroinflammation in the rat brain after cortical spreading depression.

Cui YL, Takashima T, Takashima-Hirano M, Wada Y, Shukuri M, Tamura Y, Doi H, Onoe H, Kataoka Y, Watanabe Y.
J Nucl Med, 50(11), 1904-1911 (2009).
10

Neuroprotection by a central nervous system-type prostacyclin receptor ligand demonstrated in monkeys subjected to middle cerebral artery occlusion and reperfusion: a positron emission tomography study.

Cui YL, Takamatsu H, Kakiuchi T, Ohba H, Kataoka Y, Yokoyama C, Onoe H, Watanabe Y, Hosoya T, Suzuki M, Noyori R, Tsukada H, Watanabe Y.
Stroke, 37(11), 2830-2836 (2006).

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