RIKEN Center for Life Science Technologies

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To let you know about our research, this area contains 4 types of information about CLST; “Article”, “Videos”, “Event” and “Study”.
At “Article”, you can read articles on interviews and lectures, and you can enjoy the videos about CLST at “Videos”. If you want to meet and talk directly with the researcher, “Visit” give you some information of such events. You can find more difficult contents to know about our research deeply at “Study”.
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Labs & Technologies

Drug Discovery Imaging Platform Unit

The Drug Discovery Imaging Platform Unit is advancing in vivo pharmacokinetic research of marmosets (monkeys), mice and humans by utilizing molecular imaging technology focused on positron emission tomography (PET). Labeling technologies for molecular imaging probes guarantee in vivo observation time and improve tracing after metabolic breakdown. Also, with a view to clinical studies of microdoses, we aim to build new drug discovery processes, developing labeling and probes for drug candidate compounds, as well as utilizing mice-to-human streamlined molecular imaging techniques.

Unit Leader
Yasuyoshi Watanabe  M.D.,Ph.D

6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan
Tel: +81-78-304-7101

3_7_watanabe.png

Research Area

Main Publications List

1

Exploration of Antiemetics for Osteoporosis Therapy-Induced Nausea and Vomiting Using PET Molecular Imaging Analysis to Gastrointestinal Pharmacokinetics

Shingaki T, Katayama Y, Nakaoka T, Takashima T, Onoe K, Okauchi T, Hayashinaka E, Wada Y, Cui Y, Watanabe Y.
Pharm Res., 33(5), 1235-1248 (2016).
2

Visualization and Quantitative Assessment of the Brain Distribution of Insulin through Nose-to-Brain Delivery Based on the Cell-Penetrating Peptide Noncovalent Strategy.

Kamei N, Shingaki T, Kanayama Y, Tanaka M, Zochi R, Hasegawa K, Watanabe Y, Takeda-Morishita M.
Mol Pharm., 13(3), 1004-1011 (2016).
3

Detection of cyclooxygenase-1 in activated microglia during amyloid plaque progression: PET studies in Alzheimer’s disease model mice.

Shukuri M, Mawatari A, Ohno M, Suzuki M, Doi H, Watanabe Y, Onoe H.
J Nucl Med, 57(2), 291-296 (2016).
4

Visualization of drug translocation in the nasal cavity and pharmacokinetic analysis on nasal drug absorption using positron emission tomography in the rat

Shingaki T, Katayama Y, Nakaoka T, Irie S, Onoe K, Okauchi T, Hayashinaka E, Yamaguchi M, Tanki N, Ose T, Hayashi T, Wada Y, Furubayashi T, Cui Y, Sakane T, Watanabe Y
Eur J Pharm Biopharm.,(99), 45-53 (2015).
5

Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalizations

Niwa T, Ochiai H, Watanabe Y, Hosoya T
J Am Chem Soc, 137(45), 14313-14318 (2015).
6

Synthesis of 11C-Labeled Thiamine and Fursultiamine for in Vivo Molecular Imaging of Vitamin B1 and Its Prodrug Using Positron Emission Tomography.

Doi H, Mawatari A, Kanazawa M, Nozaki S, Nomura Y, Kitayoshi T, Akimoto K, Suzuki M, Ninomiya S, Watanabe Y.
J Org Chem, 80(12), 6250-6258 (2015).
7

Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with F-18-incorporated oligodeoxynucleotides

Mukai H, Ozaki D, Cui Y, Kuboyama T, Yamato-Nagata H, Onoe K, Takahashi M, Wada Y, Imanishi T, Kodama T, Obika S, Suzuki M, Doi H, Watanabe Y.
J Control Release, 180, 92-99 (2014).
8

Evaluation of Oatp and Mrp2 Activities in Hepatobiliary Excretion Using Newly Developed Positron Emission Tomography Tracer [C-11]Dehydropravastatin in Rats

Shingaki T, Takashima T, Ijuin R, Zhang X, Onoue T, Katayama Y, Okauchi T, Hayashinaka E, Cui YL, Wada Y, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
J Pharmacol Exp Ther, 347(1), 193-202 (2013).

>>>ALL Publications

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