RIKEN Center for Life Science Technologies


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Labs & Technologies

Advanced Solid-State NMR Unit

Development and application of novel solid-state NMR methods to piering the structures and dynamics in the atomic level

Unit Leader
Yusuke Nishiyama  Ph.D.

W121, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045


Research Area

We develop novel solid-state NMR methods to understand the molecular structures and dynamics in the atomic level and apply these techniques to various materials. We have cutting edge solid-state NMR equipment including ultrafast MAS of 120 kHz and high magnetic fields up to 900 MHz. Our interest includes biomolecules, proteins, peptides, catalysis, pharmaceutical compounds, organic-inorganic hybrid materials, natural minerals etc.

Main Publications List


Ultra-fast Magic Angle Spinning: Benefits for the Acquisition of Ultra-wideline NMR Spectra of Heavy Spin-1/2 Nuclei.

P_ppler AC, Demers JP, Malon M, Singh AP, Roesky HW, Nishiyama Y, Lange A
Chemphyschem, 17(6), 812-816 (2016).

Two-dimensional proton-detected 35Cl/1H correlation solid-state NMR experiment under fast magic angle sample spinning: Application to pharmaceutical compounds

Manoj Kumar Pandey, Hiroshi Kato, Yuji Ishii, Yusuke Nishiyama
Phys Chem Chem Phys,(18), 6209-6216 (2016).

1020 MHz Single-Channel Proton Fast Magic Angle Spinning Solid-State NMR Spectroscopy.

Pandey MK, Zhang R, Hashi K, Ohki S, Nishijima G, Matsumoto S, Noguchi T, Deguchi K, Goto A, Shimizu T, Maeda H, Takahashi M, Yanagisawa Y, Yamazaki T, Iguchi S, Tanaka R, Nemoto T, Miyamoto T, Suematsu H, Saito K, Miki T, Ramamoorthy A, Nishiyama Y.
J Magn Reson, 261, 1–5 (2015).

High-resolution NMR-based metabolic detection of microgram biopsies using a 1 mm HRμMAS probe.

Nishiyama Y, Endo Y, Nemoto T, Bouzier-Sore AK, Wong A.
Analyst, 140(24), 8097-8100 (2015).

The use of a selective saturation pulse to suppress t1 noise in two-dimensional 1H fast magic angle spinning solid-state NMR spectroscopy.

Robertson AJ, Pandey MK, Marsh A, Nishiyama Y, Brown SP.
J Magn Reson., 260, 89-97 (2015).

Evolution of CPMAS under fast magic-angle-spinning at 100kHz and beyond.

Wickramasinghe A, Wang S, Matsuda I, Nishiyama Y, Nemoto T, Endo Y, Ishii Y.
Solid State Nucl Magn Reson., S0926-2040(15), 30025-4 (2015).

Nano-mole scale sequential signal assignment by 1H-detected protein solid-state NMR

Wang S, Parthasarathy S, Xiao Y, Nishiyama Y, Long F, Matsuda I, Endo Y, Nemoto T, Yamauchi K, Asakura T, Takeda M, Terauchi T, Kainoshogi M, Ishii Y.
Chem. Commun., 51, 15055-15058 (2015).

Accurate NMR determination of C–H or N–H distances for unlabeled molecules

Nishiyama Y, Malon M, Potrzebowski MJ, Paluch P, Amoureux JP.
Solid State Nucl Magn Reson., S0926-2040(15), 30005-9 (2015).

>>>ALL Publications

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