健康病態科学研究チーム _論文リスト一覧

健康・病態科学研究チーム

A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression.

Cui YL, Toyoda H, Sako T, Onoe K, Hayashinaka E, Wada Y, Yokoyama C, Onoe H, Kataoka Y, Watanabe Y.
Neuroimage, 108, 17-22 (2015).

Quantitative evaluation of mMate1 function based on minimally invasive measurement of tissue concentration using PET with [¹¹C]Metformin in mouse.

Shingaki T, Hume WE, Takashima T, Katayama Y, Okauchi T, Hayashinaka E, Wada Y, Cui Y, Kusuhara H, Sugiyama Y, Watanabe Y.
Pharm Res, in press, (2015).

¹¹C-Labeled Capsaicin and Its in Vivo Molecular Imaging in Rats by Positron Emission Tomography

Goto M, Mizuma H, Wada Y, Suzuki M, Watanabe Y, Onoe H, and Doi H.
Food Nutr Sci, 6(2), 216-220 (2015).

Role of cortical spreading depression in the pathophysiology of migraine

Cui YL, Kataoka Y, Watanabe Y.
Neurosci Bull, 30(5), 812-822 (2014).

Fatigue correlates with the decrease in parasympathetic sinus modulation induced by a cognitive challenge

Mizuno K, Tajima K, Watanabe Y, Kuratsune H.
Behav Brain Funct, 10, 25 (2014).

Pd-0-Mediated Rapid Cross-Coupling Reactions, the Rapid C-[C-11]Methylations, Revolutionarily Advancing the Syntheses of Short-Lived PET Molecular Probes

Suzuki M, Doi H, Koyama H, Zhang Z, Hosoya T, Onoe H, Watanabe Y.
Chem Rec, 14(3), 516-541 (2014).

Efficient syntheses of [C-11]zidovudine and its analogs by convenient one-pot palladium(0)-copper(I) co-mediated rapid C-[C-11]methylation

Zhang ZE, Doi H, Koyama H, Watanabe Y, Suzuki M.
J Label Compd Radiopharm, 57(8), 540-549 (2014).

[¹¹C]Cetrozole: an Improved C-[¹¹C]Methylated PET Probe for Aromatase Imaging in the Brain.

Takahashi K, Hosoya T, Onoe K, Doi H, Nagata H, Hiramatsu T, Li XL, Watanabe Y, Wada Y, Takashima T, Suzuki M, Onoe H, Watanabe Y.
J Nucl Med, 55(5), 852-857 (2014).

PET Imaging Analysis with ⁶⁴Cu in Disulfiram Treatment for Aberrant Copper Bio-distribution in Menkes Disease Mouse Model

Nomura S, Nozaki S, Hamazaki T, Takeda T, Ninomiya E, Kudo S, Hayashinaka E, Wada Y, Hiroki T, Fujisawa C, Kodama H, Shintaku H, Watanabe Y.
J Nucl Med, 55(5), 845-851 (2014).

Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with F-18-incorporated oligodeoxynucleotides

Mukai H, Ozaki D, Cui Y, Kuboyama T, Yamato-Nagata H, Onoe K, Takahashi M, Wada Y, Imanishi T, Kodama T, Obika S, Suzuki M, Doi H, Watanabe Y.
J Control Release, 180, 92-99 (2014).

Human whole-body biodistribution and dosimetry of a new PET tracer, [(11)C]ketoprofen methyl ester, for imagings of neuroinflammation.

Ohnishi A, Senda M, Yamane T, Sasaki M, Mikami T, Nishio T, Ikari Y, Nishida H, Shukuri M, Takashima T, Mawatari A, Doi H, Watanabe Y, Onoe H
Nucl Med Biol, 41(7), 594-599 (2014).

Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: an ¹¹C-(R)-PK11195 PET study.

Nakatomi Y, Mizuno K, Ishii A, Wada Y, Tanaka M, Tazawa S, Onoe K, Fukuda S, Kawabe J, Takahashi K, Kataoka Y, Shiomi S, Yamaguti K, Inaba M, Kuratsune H, Watanabe Y.
J Nucl Med, 55(6), 945-950 (2014).

Brain Interleukin-1 beta and the Intrinsic Receptor Antagonist Control Peripheral Toll-Like Receptor 3-Mediated Suppression of Spontaneous Activity in Rats

Yamato M, Tamura Y, Eguchi A, Kume S, Miyashige Y, Nakano M, Watanabe Y, Kataoka Y.
PLoS One, 9(3), e90950 (2014).

The synthesis and biodistribution of [C-11]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo

Hume WE, Shingaki T, Takashima T, Hashizume Y, Okauchi T, Katayama Y, Hayashinaka E, Wada Y, Kusuhara H, Sugiyama Y, Watanabe Y.
Bioorg Med Chem, 21(24), 7584-7590 (2013).

Positron emission tomography study on pancreatic somatostatin receptors in normal and diabetic rats with Ga-68-DOTA-octreotide: A potential PET tracer for beta cell mass measurement

Sako T, Hasegawa K, Nishimura M, Kanayama Y, Wada Y, Hayashinaka E, Cui YL, Kataoka Y, Senda M, Watanabe Y.
Biochem Biophys Res Commun, 442(1-2), 79-84 (2013).

⁶⁴Cu-DOTA-trastuzumab PET imaging in patients with HER2-positive breast cancer.

Tamura K, Kurihara H, Yonemori K, Tsuda H, Suzuki J, Kono Y, Honda N, Kodaira M, Yamamoto H, Yunokawa M, Shimizu C, Hasegawa K, Kanayama Y, Nozaki S, Kinoshita T, Wada Y, Tazawa S, Takahashi K, Watanabe Y, Fujiwara Y.
J Nucl Med, 54(11), 1869-1875 (2013).

Investigation of the Effect of Active Efflux at the Blood-Brain Barrier on the Distribution of Nonsteroidal Aromatase Inhibitors in the Central Nervous System

Miyajima, M; Kusuhara, H; Takahashi, K; Takashima, T; Hosoya, T; Watanabe, Y; Sugiyama, Y
J Pharm Sci, 102(9), 3309-3319 (2013).

The synthesis of 64Cu-chelated porphyrin photosensitizers and their tumor-targeting peptide conjugates for the evaluation of target cell uptake and PET image-based pharmacokinetics of targeted photodynamic therapy agents.

Mukai H., Wada Y., Watanabe Y.
Ann Nucl Med, 27(7), 625-639 (2013).

Synthesis of an ¹¹C-Labeled Antiprion GN8 Derivative and Evaluation of Its Brain Uptake by Positron Emission Tomography

Kimura T, Sako T, Siqin, Hosokawa-Muto J, Cui YL, Wada Y, Kataoka Y, Doi H, Sakaguchi S, Suzuki M, Watanabe Y, Kuwata K.
ChemMedChem, 8(7), 1035-1039 (2013).

Dynamic analysis of fluid distribution in the gastrointestinal tract in rats: positron emission tomography imaging after oral administration of nonabsorbable marker, [(18)F]Deoxyfluoropoly(ethylene glycol).

Takashima T, Shingaki T, Katayama Y, Hayashinaka E, Wada Y, Kataoka M, Ozaki D, Doi H, Suzuki M, Ishida S, Hatanaka K, Sugiyama Y, Akai S, Oku N, Yamashita S, Watanabe Y
Mol Pharm, 10(6), 2261-2269 (2013).

A conformationally fixed analog of the peptide mimic Grb2-SH2 domain: synthesis and evaluation against the A431 cancer cell.

Iwata T, Tanaka K, Tahara T, Nozaki S, Onoe H, Watanabe Y, Fukase K.
Mol Biosyst, 9(5), 1019-1025 (2013).

Endogenous compounds labeled with radionuclides of short half-life—some perspectives.

Långström B, Karimi F, Watanabe Y.
J Labelled Compd Rad, 56(3-4), 251-262 (2013).

Neurocognitive impairment in childhood chronic fatigue syndrome.

Mizuno K, Watanabe Y.
Front Physiol, 4, 87 (2013).

Detection of early stage atherosclerotic plaques using PET and CT fusion imaging targeting P-selectin in low density lipoprotein receptor-deficient mice.

Nakamura I, Hasegawa K, Wada Y, Hirase T, Node K, Watanabe Y.
Biochem Biophys Res Commun, 433(1), 47-51 (2013).

Osmotic release oral system-methylphenidate improves neural activity during low reward processing in children and adolescents with attention-deficit/hyperactivity disorder.

Mizuno K, Yoneda T, Komi M, Hirai T, Watanabe Y, Tomoda A.
Neuroimage Clin, 2, 366-376 (2013).

Novel Molecular Imaging of Atherosclerosis With Gallium-68-Labeled Apolipoprotein A-I Mimetic Peptide and Positron Emission Tomography

Kawachi E, Uehara Y, Hasegawa K, Yahiro E, Ando S, Wada Y, Yano T, Nishikawa H, Shiomi M, Miura S, Watanabe Y, Saku K.
Circ J, 77(6), 1482-1489 (2013).

Imaging of gastrointestinal absorption and biodistribution of an orally administered probe using positron emission tomography in humans.

Shingaki T, Takashima T, Wada Y, Tanaka M, Kataoka M, Ishii A, Shigihara Y, Sugiyama Y, Yamashita S, Watanabe Y.
Clin Pharmacol Ther, 91(4), 653-659 (2012).

健康・病態科学研究チーム

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